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Several of the region's universities (notably the University of Rochester and Rochester Institute of Technology) have renowned research programs.

In addition, Rochester is the site of many important inventions and innovations in consumer products.

Douglass, a former slave and an antislavery speaker and writer, gained a circulation of over 4,000 readers in the United States, Europe and the Caribbean.At the end of the 19th century, anarchist Emma Goldman lived and worked in Rochester for several years, where she championed the cause of labor in Rochester sweatshops.Rochester was also home to significant unrest in labor, race, and antiwar protests.By 1838, Rochester was the largest flour-producing city in the United States.Having doubled its population in only 10 years, Rochester became America's first "boomtown".

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